Multi-tip punches are a cost-effective way to increase tablet output without the need for additional tablet presses. The use of multi-tip punches follows a similar principle as a single tip tool for the rotary tablet press but there are operating techniques that must be understood for a successful tableting process 

This article and case study will point out the critical stages of the rotary tablet press process, describe what impact multi-tip punches have at each step, and how to overcome the common challenges found in the tablet compression industry.  Data will also be provided to address the impact multi-tip punches have on compression forces. There are six areas of concern during the tableting process in which multi-tip punches are directly affected. Each of these areas may need to be addressed when moving from a single tip to a multitip punch set up.

  1. Hopper Level Product is initially loaded into the hopper of a tablet press and the powder must have adequate flow properties to successfully enter the feeder system. The amount of product in the hopper will determine the head pressure of the powder and this pressure can impact tablet weight. Keeping a constant head pressure can help minimize weight variation issues. When multi-tip punches are installed on the press the rate of product consumed is significantly increased and requires loading the hopper more often.
  2. Feeder Speed The feeder delivers the powder from the hopper to the die table. Using multitip punches, more product will need to be drawn from the feeder, requiring a higher feeder speed than is used for single-tip punches.
  3. Die Fill Process The lower punch is pulled down from the fill cam to allow overfill of the die cavity. The excess powder is then pushed out when the punch reaches the dosing cam. A worn-out tool, or a low-quality tool that is not within specification, can cause weight issues and punch binding as materials build up on the die wall. Multi-tip punches can exacerbate these issues and require special attention to tool quality. The selection of the proper fill cam is critical for single tip and multi-tip tools. Powder over-blending is a common issue when the fill cam size is excessive and the recycled material re-enters back into the feeder and is potentially over blended from paddle feeders mixing. This over blending phenomenon is potentially minimized when dealing with multi-tip punches as the powder feeder residence time is significantly reduced. As the number of tips are increased on a punch and the appropriate size fill cam is installed the over blending potential is minimized.
  4. Pull-Down Cam Immediately following the dosing cam is either a tail-over die or pull-down cam. Both are designed to keep the powder in the die cavity before the upper punch enters the die. When utilizing multi-tip punches it is imperative that the pull down cam doesn’t pull the lower tip from the die cavity. This modification should be treated similar to that of the fill cam.
  5. Pre-Compression Pre compression is a de-aeration stage. This allows the removal of air and initial consolidation of particles to help with the main compression process. A multitip application may also benefit from the use of pre-compression, but with the increased number of tablets produced, the press speed can be reduced. This reduction in speed increases dwell and total compression time, possibly eliminating the need for pre compression.
  6. Main Compression The final compression force on the rotary tablet press is a result of the amount of powder in the die cavity and the distance between the upper and lower punch tips. Assuming a concentric pressure roller and punches that are within working length tolerance, the resulting compression force will be similar for each turret station if the powder is uniform in fill. It is of special importance that the multi-tip punch working lengths are within tolerance since these force systems have no way of determining which tip is causing the issue. 


A series of experiments were conducted to study the compression force impact from a single-tip, two-tip and fourtip 0.25” (6.35mm) round tool. The tools are illustrated in Figure 1. A direct compression blend consisting of 25% w/w of APAP and 74.5% SMCC 50 with 0.5% magnesium stearate was used for the study. A compaction profile study was performed on a bench-top rotary tablet press at 25RPM turret speed. Tablets were collected at varying force levels for each tool configuration. Resulting tablets were measured for thickness, weight, and breaking force. Figure 1 depicts the compaction profile for the three tools. It is clear the compression force of multi-tip tooling must increase to achieve the same tablet breaking force as the number of tips are increased. One might think that since the area of the tool has doubled, it would require twice the force to achieve the same tablet breaking force as is illustrated in Figure 2, but this may not be the case. Figure 3 is the compaction profile normalized for the tablet geometry and punch tip area. This gives a clearer picture of the resulting tablet strengths at different applied compaction pressures.

If in fact the force is doubled when the tool area is doubled then the plots would superimpose. At the same compaction pressure, the 2-tip tool configuration results in a 19% increase in tablet strength, and another 19% increase in strength from a 2-tip to a 4-tip configuration. In this case study, the applied pressure or compression force would be less than double to achieve the same tablet strength.

Ejection After the tablet is compressed the ejection cam will push the lower punch upward to eject the tablet. The ejection force is a combination of the residual radial die wall and coefficient of friction between the tablet belly band surface and the die wall surface. Excessive ejection force levels will cause premature wear to the lower punches, cams and may cause visual striations on the tablet’s belly band. Multi-tip punches increase the belly band surface due to the increased number of tablets. This inherently increases ejection force levels and the likelihood of having the aforementioned issues. Common ways to reduce the ejection force includes increased levels of powdered lubricant to the formulation (i.e. magnesium stearate), tapered dies and lined dies of different materials.

What Impact Do Multi-tip Punches Have on Ejection Force? As previously mentioned, as the number of tips are increased on the punch, the number of tablets ejected also increases and an increase in ejection force is expected. If the contact area is doubled, one would assume the force would be doubled as well. The results are depicted in Figure 4. The results clearly show a significant increase in ejection force with the increased number of tips but it is not doubled or linear. The properties of the powder play a major role in the ejection forces. When lubrication is excessive the ejection force will not increase with increased compression force since the friction is reduced. This profile finds value in the development arena where lubrication can be optimized. Lower levels of lubricant can reduce capping potential, improve tablet strengths and disintegration/dissolution times.

Tablet Take Off   The final step on the rotary tablet press is the tablet take-off or tablet removal from the lower punch face. Common problems associated with tablet take off are sticking and picking issues. There are many techniques available to remediate these issues including steel composition, punch face coatings, and logo designs, but when dealing with multi-tip punches the punch overall length is of particular importance. Most tablet presses are designed so that the lower punch tip is flush with the top of the die table to ensure a smooth tablet removal process. Some presses are designed to protrude the lower tips at 0.5mm or more. If the overall lengths are not consistent within a set of punches the tablet removal process may have issues with the tips damaging the take-off bar or even the leading edge of the feeder. If the punch tip is slightly below the die table surface the tablet might fracture at the take-off bar. For multi-tip punches, it is favourable to provide a flush tip situation versus a slightly protruded tip since the latter can cause tablet damage from the trailing protruded tips contacting the leading tablets that were removed from the take-off bar.

Conclusion This study provides some intriguing information about the necessary compression forces for multi-tip tooling. As manufacturers often look to reduce costs and increase productivity, wear on tablet presses and tooling can be a concern. With the potential ability to reduce some compression forces necessary to produce quality tablets, opponents to multi-tip punches may have one less reason to be concerned. A full understanding of the available options and the impact they have on the rotary tablet press are key to successful manufacturing. If you are considering multi-tip punches, be sure to work with a reputable tooling manufacturer to discuss all options and determine what solutions will work best for your company. Natoli Engineering Company, Inc., is the world-renowned leader in tablet compression tooling, support products, and services. Founded on the uncompromising principle to manufacture and deliver the highest quality products at a fair price with exceptional customer service, Natoli continues to build on a half century of innovation and industry leadership.



DOES NOT COMPUTE : When and how Pharmaceutical Automation fails more…


THE WAY FORWARD FOR PHARMA : Pharma 4.0 – Part 2 more…

In Focus


CAM -Traceability Solutions on Show  more…



Did You Know? more…

error: Content is protected !!